Author

Sandy Mattijssen

National Institutes of HealthORCID 0000-0002-4285-7438Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Richard J MaraiaiD· 3 shared Amitabh Ranjan· 2 shared Abdul KhaliqueiD· 1 shared Acong YangiD· 1 shared Alexander F. HaddadiD· 1 shared Chen G. Han· 1 shared Isabel Cruz‐GallardoiD· 1 shared James IbeniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMolecular Biology

Richard J MaraiaORCID

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3 papers

Recent·Most cited

The short conserved region-2 of LARP4 interacts with ribosome-associated RACK1 and promotes translation

Amitabh Ranjan, Sandy Mattijssen, Nithin Charlly, Isabel Cruz‐Gallardo, Leah F. Pitman F. Pitman, Jennifer C. Coleman, Maria R. Conte, Richard J Maraia

The paper identifies a conserved region in LARP4 that interacts with RACK1 to enhance translation of specific mRNAs.

Nucleic Acids Research · Jan 24, 2025Peer-reviewedMolecular Biology

A POLR3B-variant reveals a Pol III transcriptome response dependent on La protein/SSB

Sandy Mattijssen, Kyra Kerkhofs, Joshi Stephen, Acong Yang, Chen G. Han, Yokoyama Tadafumi, James Iben, Saurabh Mishra, Rima M. Sakhawala, Amitabh Ranjan, Mamatha Gowda, William Allen Gahl, Shuo Gu, May Christine V. Malicdan, Richard J Maraia

The paper identifies a POLR3B variant causing mis-splicing and altered Pol III transcriptome, revealing La protein's role in reshaping small ncRNA profiles and identifying tRF-1/tRF-3 as biomarkers for POLR3 deficiency.

bioRxiv · Feb 5, 2024 · PreprintMolecular Biology

Targeting of mitochondrial and cytosolic substrates of tRNA isopentenyltransferases: selection of differential tRNA-i6A37 identity subsets

Abdul Khalique, Sandy Mattijssen, Alexander F. Haddad, Shereen Chaudhry, Richard J Maraia

This paper identifies the mitochondrial targeting sequence of TRIT1 and shows its substrate specificity for tRNAs with specific anticodons.

PLoS Genetics · Apr 23, 2020Peer-reviewedGenetics