István N. Huszár

Hierarchical X-ray microscopy and mesoscopic diffusion MRI in the same brain reveal the human connectome across scales

The paper presents a multimodal imaging pipeline that combines diffusion MRI and high-resolution X-ray microscopy to map the human connectome across multiple scales.

Linking microscopy to diffusion MRI with degenerate biophysical models: an application of the Bayesian EstimatioN of CHange (BENCH) framework

The paper applies the BENCH framework to link diffusion MRI signal changes to microstructural features in brain tissue using histology data.

Precise MRI-Histology Coregistration of Paraffin-Embedded Tissue with Blockface Imaging

This paper develops a pipeline for precise MRI-histology coregistration using blockface imaging, achieving high alignment accuracy for neurodegenerative disease research.

Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain

This study compares hippocampal structure and function across humans and macaques to show conservation of micro- and macro-structure but evolutionary reconfiguration in functional connectivity.

The BigMac dataset: an open resource combining multi-contrast MRI and microscopy in the macaque brain

The paper introduces the BigMac dataset, combining multi-contrast MRI and microscopy data from a macaque brain, enabling multimodal analysis across scales and tissue states.

Tensor Image Registration Library: Automated Deformable Registration of Stand-Alone Histology Images to Whole-Brain Post-Mortem MRI Data

The paper introduces an automated pipeline for registering stand-alone histology sections to whole-brain MRI data with sub-voxel accuracy.

An automated pipeline for extracting quantitative histological metrics for voxelwise MRI-histology comparisons

This paper introduces an automated pipeline to extract quantitative histological metrics for voxelwise MRI-histology comparisons and finds activated microglia strongly predicts DTI FA, suggesting diffusion MRI sensitivity to neuroinflammation.

Tensor Image Registration Library: Automated Non-Linear Registration of Sparsely Sampled Histological Specimens to Post-Mortem MRI of the Whole Human Brain

The paper introduces a pipeline for automatically aligning histological images with whole-brain MRI data, achieving sub-millimetre accuracy and outperforming manual methods.

White matter changes in the perforant path in patients with amyotrophic lateral sclerosis

This study investigates white matter degeneration in the perforant path of ALS patients using diffusion MRI, polarized light imaging, and immunohistochemistry, finding significant changes in fractional anisotropy and myelin density.