Hiroyuki Kamiya

This study uses a mutagenesis assay to show that single DNA lesions from oxidative damage can trigger strand-biased mutations at specific DNA sites.

The paper develops a high-throughput mutagenesis assay using DNA-barcoded supF shuttle vectors and NGS to study mutation frequencies and spectra in E. coli.

This study shows PHF1 and PHF19 Tudor domains preferentially bind H3tK27me3 over canonical H3K27me3, revealing structural basis for their recognition.