A CRISPR-associated Rossman-fold Ring Nuclease and Adenosine Deaminase Fusion Allosterically Converts ATP to ITP
Charlisa Whyms, Yu Zhao, Doreen Addo-Yobo, Huan He, Arthur Carl Whittington, Despoina Trasanidou, Carl Raymund P. Salazar, Raymond H.J. Staals, Hong Li
This paper identifies a CRISPR-associated protein, Cad1, that converts ATP to ITP in a cOA-dependent manner through an allosteric mechanism.
The EMBO Journal · Oct 17, 2025Peer-reviewedCell Biology