Arthur Carl Whittington

This study uses Topiary to reconstruct and characterize ancestral HK enzymes, revealing evolutionary changes in allosteric regulation within the HK family.

This study identifies the evolutionary emergence of redox sensitivity in vertebrate glucokinases through conformational expansion and cysteine residue acquisition.

This study identifies a single mutation that enables GKRP to gain small-molecule allostery through structural co-optation, without requiring new genetic material.

This paper reconstructs extinct glucokinase (GCK) and glucokinase regulatory protein (GKRP) to study the evolutionary origins of protein regulation in vertebrate glucose homeostasis.

This paper identifies a CRISPR-associated protein, Cad1, that converts ATP to ITP in a cOA-dependent manner through an allosteric mechanism.