Wenfeng Qian

Distance-dependent inhibition of translation initiation by downstream out-of-frame AUGs reveals that ribosome scans in a Brownian ratchet process

The paper shows that downstream out-of-frame AUGs inhibit translation initiation at the annotated AUG, with diminishing effect over distance, supporting a Brownian ratchet model of ribosome scanning.

Single-cell transcriptome analyses recapitulate the cellular and developmental responses to abiotic stresses in rice

This study uses single-cell RNA sequencing to analyze rice cell responses to abiotic stresses, identifying cell-type-specific gene expression changes and population dynamics.

Disome-seq reveals widespread ribosome collisions that recruit co-translational chaperones

The paper uses disome-seq to detect ribosome collisions during translation, revealing their role in recruiting co-translational chaperones for protein folding.

Overdosage of balanced protein complexes reduces proliferation rate in aneuploid cells

The paper shows that overdosage of balanced protein complexes reduces proliferation in aneuploid yeast and human cancer cells.

DNA local structure decreases mutation rates

The paper shows that DNA curvature affects mutation rates in yeast and human tumors, with lower curvature linked to higher mutation rates.