Chaorui Duan

Gut delivery of pentameric GLP-1 using genetically engineered Bacillus subtilis

This paper develops an engineered Bacillus subtilis spore system for sustained gastrointestinal delivery of pentameric GLP-1, showing glucose-lowering and weight-reduction effects in mice.

Elevated levels of intracellular RNA lariats suppress the antiviral response

The paper shows that accumulation of intracellular RNA lariats in DBR1-null cells reduces antiviral response by desensitizing dsRNA sensors.

One-Size-Fits-Many: Antisense oligonucleotides for rescuing splicing mutations in hotspot exons

The paper identifies splice-disrupting mutations in hotspot exons and shows that antisense oligonucleotides (ASOs) can revert splicing defects in these exons.

Large scale functional screen identifies genetic variants with splicing effects in modern and archaic humans

The paper identifies splicing variants in modern and archaic humans using functional assays and shows differences in purifying selection and adaptive introgression.

DNA local structure decreases mutation rates

The paper shows that DNA curvature affects mutation rates in yeast and human tumors, with lower curvature linked to higher mutation rates.