Spatially organized cancer-associated fibroblast subtypes partition cutaneous carcinomas into immune-active and contracted, immune-repressed niches
Bertram Aschenbrenner, Agnes Forsthuber, Jakob Jessen…·Beate M. Lichtenberger
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Medical University of ViennaORCID 0000-0001-6882-0257Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Bertram Aschenbrenner, Agnes Forsthuber, Jakob Jessen…·Beate M. Lichtenberger
Anela Tosevska, Karolina von Dalwigk, Peter Heil…·Thomas Karonitsch
This study identifies NNMT as a key driver of fibroblast activation and skin fibrosis in systemic sclerosis by modulating TGFβ signaling and ECM production.
Lloyd Steele, Bayanne Olabi, Kenny Roberts…·Muzlifah A. Haniffa
This study creates a spatial genomics atlas of human skin fibroblasts in health and disease, identifying six major populations and three disease-specific subtypes.
Jodie Bojko, Elodie Sins, Benjamin P. Flynn…·Gernot Walko
This study identifies YAP's interaction with RIF1 in squamous cell carcinoma, showing it reduces replication stress-induced DNA damage through non-transcriptional mechanisms.