Anela Tosevska

Time-resolved immune dynamics in rheumatoid arthritis under Methotrexate therapy

This study uses scRNA-seq and immunophenotyping to analyze immune changes in RA patients on MTX, showing early restoration of naive T/B cells and reduced memory T cells, with plasmablasts as a potential biomarker.

SummArIzeR: Simplifying cross-database enrichment result clustering and annotation via large language models

SummArIzeR clusters and annotates cross-database enrichment results using large language models, providing fast and unbiased interpretation of biological data.

Nicotinamide N-Methyltransferase drives fibroblast activation and skin fibrosis in systemic sclerosis

This study identifies NNMT as a key driver of fibroblast activation and skin fibrosis in systemic sclerosis by modulating TGFβ signaling and ECM production.

Preserved suppressive function despite loss of Foxp3: insights into the identity of regulatory T cells

This study shows that regulatory T cells can maintain suppressive function and a Treg signature even when Foxp3 expression is lost in Th2-driven disease models.

Targeting histone acetylation enables epigenetic modulation of inflammatory pathways, a novel therapeutic strategy for rheumatoid arthritis

This study screens histone acetylation inhibitors to modulate immune pathways in RA, showing concentration-dependent effects and overlap with existing RA drug pathways.

A rapid platform for 3D patient-derived cutaneous neurofibroma organoid establishment and screening

This paper introduces a platform for establishing and screening patient-derived cutaneous neurofibroma organoids to support drug discovery for NF1-associated tumors.

Tissue informative cell-free DNA methylation sites in amyotrophic lateral sclerosis

The paper identifies tissue-informative DNA methylation sites in ALS using targeted sequencing and machine learning, showing accurate prediction of disease status and progression.

BiSulfite Bolt: A BiSulfite Sequencing Analysis Platform

BSBolt is a bisulfite sequencing analysis platform that provides accurate and fast alignment and methylation calling, outperforming existing tools.