Chen‐Leng Cai

This study shows that ZEB2 is essential for ureteral smooth muscle cell differentiation and maintenance, as its deletion in mice causes hydroureter and hydronephrosis.

The paper develops a new Myh11-driven Cre mouse model for precise SMC-specific gene manipulation, avoiding issues of off-target activity and variable integration seen in existing models.

This study shows that endocardial HDAC3 is essential for myocardial trabeculation by regulating TGFβ3 expression through miR-129-5p repression in mice.

This study shows that HDAC3 in the epicardium promotes myocardial growth by regulating FGF9 and IGF2 through miR-322/miR-503 repression.

This study identifies a Tbx1-dependent multilineage primed population in the murine cardiopharyngeal mesoderm using single-cell RNA-sequencing and shows its role in cardiac and skeletal muscle development.