Jiliang Zhou

Neddylation Regulates Mitochondrial Dynamics and Turnover in the Adult Heart

This study shows that neddylation regulates mitochondrial dynamics and turnover in the adult heart, linking its disruption to cardiomyopathy and heart failure.

Generation of a novel constitutive smooth muscle cell-specific Myh11-driven Cre mouse model

The paper develops a new Myh11-driven Cre mouse model for precise SMC-specific gene manipulation, avoiding issues of off-target activity and variable integration seen in existing models.

TEAD1 is crucial for developmental myelination, Remak bundles and functional regeneration of peripheral nerves

This study shows TEAD1 is essential for Schwann cell myelination, regeneration, and Remak bundle formation through mechanisms involving proliferation control and cholesterol biosynthesis.

Discovery of an evolutionarily conserved smooth muscle cell-specific lncRNA CARMN

The paper identifies CARMN as an evolutionarily conserved, smooth muscle cell-specific lncRNA, showing its down-regulation in vascular diseases and functional importance in maintaining the contractile phenotype of vascular smooth muscle cells.