Nicholas Francis Fitz

The paper integrates transcriptomic data from brain tissue and plasma extracellular vesicles in a tauopathy mouse model, identifying shared non-coding RNA signatures that reflect central nervous system changes.

This study develops an in vivo method to collect brain-derived extracellular vesicles from mouse models and identifies unique small ncRNA signatures associated with Alzheimer's disease.

This study investigates the cell-specific transcriptional responses to bexarotene in Alzheimer's disease mouse models, revealing APOE's role in RXR-mediated neuroprotection.

The paper identifies early vascular remodeling features in Alzheimer's disease using cross-species analysis linking mouse and human data.

The paper evaluates transcriptomic changes in muscle, brain, and plasma EVs of WT and Klotho-deficient mice after NMES, showing genotype-specific responses in metabolic and immune pathways.