Ian T. Hoffecker

Resolving multivalent antibody binding states with defined spatial antigen-patterning

This paper introduces PANMAP, a new assay that measures antibody avidity profiles by controlling antigen spacing, revealing how spatial constraints affect binding equilibria.

Spatial Coherence in DNA Barcode Networks

The paper introduces spatial coherence as a framework to evaluate spatial fidelity in DNA barcode networks for sequencing-based microscopy.

Hidden network preserved in Slide-tags data allows reference-free spatial reconstruction

The paper reanalyzes Slide-tags data to reveal a latent spatial network enabling reference-free tissue reconstruction.

Modification of RNAs in natural rG4 (MoRNiNG), A Database of RNA Modification Sites Associated with the Dynamics of RNA Secondary Structures

The paper introduces MoRNiNG, a database of RNA modification sites associated with RNA secondary structure dynamics, and validates the impact of modifications on G-quadruplex formation.

Image recovery from unknown network mechanisms forDNA sequencing-based microscopy

The paper introduces a graph-based method to reconstruct molecular networks from DNA sequencing data, achieving accurate spatial recovery with minimal assumptions.

A Computational Framework for DNA Sequencing-Based Microscopy

The paper introduces a computational framework to reconstruct spatial information from DNA sequencing data by analyzing polony adjacency networks.