Chun Kit Kwok

The paper identifies dysregulated RNA G-quadruplex binding proteins (RG4BPs) in Alzheimer's Disease, linking their altered expression to glial cell dysfunction and stress state shifts.

The paper introduces MoRNiNG, a database of RNA modification sites associated with RNA secondary structure dynamics, and validates the impact of modifications on G-quadruplex formation.

This study maps G-quadruplexes in skeletal muscle stem cells and shows their role in promoting activation and regeneration through chromatin looping and transcription factor binding.

The paper maps G-quadruplexes across the human genome and haplotypes, showing their enrichment in repetitive regions and association with genomic instability and PRDM9 binding.

Quadrupia identifies and characterizes G-quadruplex sequences across 108,449 genomes, revealing taxonomic patterns and experimentally validating key structures.

This study shows DHX36 binding remodels RNA structure, particularly in 3UTRs, leading to decreased mRNA abundance via m6A and YTHDF1 interactions.

The paper identifies G-quadruplex structures in cold-adapted plants, showing they enhance mRNA stability and improve cold response.

The paper identifies G-quadruplex motifs enriched near splice junctions and shows their involvement in alternative splicing in neuronal cells.

This study introduces rG4-seq 2.0, an improved method for detecting RNA G-quadruplexes with lower RNA input requirements and better library quality.

rG4-seeker improves rG4-seq analysis by reducing false positives and enhancing detection of non-canonical rG4 motifs in human RNA.