Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail
Joel A. Sexton, Tony Potchernikov, Jeffrey P. Bibeau, Gabriela Casanova‐Sepúlveda, Wenxiang Cao, Hua Jane Lou, Titus J. Boggon, Enrique M. De La Cruz, Benjamin E. Turk
The paper identifies sequence requirements for cofilin function and regulation by screening variants in yeast, showing that conservation is driven by the need to maintain phosphorylation capacity rather than direct function.
Nature Communications · Feb 16, 2024Peer-reviewedMolecular Biology