Titus J. Boggon

The paper examines how RASA1 mutations affect RasGAP protein function, identifying distinct mutation classes and highlighting the C2 domain's unique regulatory role.

The paper optimizes conditions for GTP loading of H-Ras by evaluating factors like time, temperature, concentration, and mutations to enhance nucleotide exchange efficiency.

This paper reports a unique crystal structure of the c-Src SH3 domain mediated by nickel ions, revealing a 2:2 stoichiometry and dimerization mechanism.

This study shows the C2 domain enhances Ras GTPase activating protein catalytic activity by interacting with the Ras allosteric lobe, as demonstrated through structural analysis and mutation studies in mice and SynGAP.

The paper identifies sequence requirements for cofilin function and regulation by screening variants in yeast, showing that conservation is driven by the need to maintain phosphorylation capacity rather than direct function.

The paper identifies genetic variants in RASA1 and EPHB4 associated with vein of Galen malformations through exome analysis and single-cell transcriptomics.