Benjamin E. Turk

This study characterizes SYDE1 and SYDE2 as JNK substrates with GAP activity toward RhoA, Rac1, and Cdc42, and shows their role in cell morphology and migration.

The paper examines the molecular effects of seven KRAS mutant variants in pancreatic cancer cells and finds that baseline cellular state, not allele identity, primarily drives molecular variation.

The paper identifies sequence requirements for cofilin function and regulation by screening variants in yeast, showing that conservation is driven by the need to maintain phosphorylation capacity rather than direct function.

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.