Chen Tan

This paper introduces DropHiChew and loop velocity to study DNA movement dynamics, enabling accurate trajectory estimation with shallow sequencing.

This study identifies DAXX as a regulator of LINE1 silencing during spermatogenesis in mice, showing its role in maintaining DNA methylation and preventing transposable element activation.

The study reconstructs the Yunxian 2 cranium and shows it belongs to the Homo longi clade, likely including Denisovans, and is closely related to the H. sapiens clade.

The paper identifies CEP192 as a novel disease gene linked to mosaic variegated aneuploidy syndrome with tetraploidy and male infertility through genetic analysis and mouse models.

The paper improves RNA velocity analysis by incorporating long-read single-cell sequencing to better capture gene expression dynamics and cell fate transitions.