Chen Zhang

This paper introduces DropHiChew and loop velocity to study DNA movement dynamics, enabling accurate trajectory estimation with shallow sequencing.

This study introduces SCA-seq to resolve spatial chromatin interactions at single-molecular resolution and demonstrates its application in analyzing epigenomic markers.

The paper investigates how enhancer interactomes reconfigure during senescence and aging, identifying hyper-connected enhancer communities linked to gene expression and potential therapeutic targets.

The paper improves RNA velocity analysis by incorporating long-read single-cell sequencing to better capture gene expression dynamics and cell fate transitions.

This study introduces TEAM-seq, a method for high-coverage 5mC sequencing in single cells, achieving 70% coverage at 100pg input DNA.

The paper introduces a method called BIND&MODIFY to map histone modifications at the single-molecule level using long-read sequencing, revealing long-range chromatin states and heterogeneity.

The paper introduces CCDA-seq to study ecDNA chromatin structure, revealing distinct nucleosome and regulator binding patterns.