Spatially Interacting Phosphorylation Sites and Mutations in Cancer
Kuan‐lin Huang, Adam David Scott, Daniel Cui Zhou, Liang-Bo Wang, Amila Weerasinghe, Abdülkadir Elmas, Ruiyang Liu, Yige Wu, Michael C. Wendl, Matthew A. Wyczalkowski, Jessika Baral, Sohini Sengupta, Chin‐Wen Lai, Kelly V. Ruggles, Samuel H. Payne, , Li Ding
The paper introduces HotPho, a tool that identifies 3D co-clustering of phosphosites and cancer mutations on protein structures, revealing 474 hybrid clusters with potential functional significance.
Nature Communications · Apr 19, 2021Peer-reviewedBioinformatics