Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer
Caleb Cheng, Jing Hu, Rahul Mannan, Tongchen He, Rupam Bhattacharyya, Brian Magnuson, Jasmine P. Wisniewski, Sydney Peters, Saadia A. Karim, David MacLean, Hüseyin Karabürk, Li Zhang, Nicholas J. Rossiter, Yang Zheng, Lanbo Xiao, , Arul M. Chinnaiyan
This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.
Nature · Apr 23, 2025Peer-reviewedCancer Biology