Jing Hu

This study identifies a stress-lipid kinase axis in NEPC driven by PIKfyve, revealing a synthetic vulnerability between PIKfyve and FASN that can be exploited for therapeutic targeting.

MitoTracer identifies informative mitochondrial mutations for lineage reconstruction from scRNA-seq and scATAC-seq data, showing high sensitivity and specificity.

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.