Author

David MacLean

Cancer Research UK Scotland InstituteORCID 0000-0003-4932-2839Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:mouse· 1

Frequent Co-Authors

Arul M. ChinnaiyaniD· 1 shared Brian MagnusoniD· 1 shared Caleb ChengiD· 1 shared Chungen LiiD· 1 shared Costas Andreas LyssiotisiD· 1 shared Dominik AwadiD· 1 shared Ester M. HammondiD· 1 shared Geoff Stuart HigginsiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Arul M. ChinnaiyanORCID

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2 papers

Recent·Most cited

Cancer BiologyCell Death and DiseasePeer-reviewedJul 22, 2025

UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment by regulating tumour cell fate

Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai…·Monica M. Olcina

This study shows hypoxia induces intracellular C5aR1 via UPR, promoting tumour cell survival by regulating autophagy and apoptosis.

6 citations

humanexperimental assay

𝕏 PostBluesky

Cancer BiologyNaturePeer-reviewedApr 23, 2025

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

Caleb Cheng, Jing Hu, Rahul Mannan…·Arul M. Chinnaiyan

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

79 citationstop 1%

𝕏 PostBluesky