Engineering antigen-driven co-stimulation and T helper cell activity into TCR-T cells with CD8-41BB fusion receptors enhances anti-tumor activity
Ivy Dutta, Justin Oh, Liz Cam, Allie Luther, Palak Sharma, Ishina Balwani, James Peter, Dai Liu, Ian C. Miller, James R. Bowen, Lekshmi Maya, Jingyu Peng, Eleni Stampouloglou, Qingzhan Zhang, Yoko Kosaka, , Aaron Prodeus
This paper enhances TCR-T cell anti-tumor activity by engineering CD8-41BB fusion receptors, improving CD4+ and CD8+ T cell functions and tumor regression in mouse models.
bioRxiv · Jul 28, 2026 · PreprintSynthetic Biology