Lucia Carbone

This study shows maternal obesity causes sex-dependent epigenetic and transcriptomic changes in offspring hearts, leading to sex-specific cardiac remodeling and disease risk.

This study shows that early-life wildfire smoke exposure in rhesus macaques leads to long-term immune and epigenetic changes, including altered cytokine responses and accelerated epigenetic aging.

The paper identifies differentially expressed genes in the parabrachial nucleus of two Xenopus frog species, linking them to vocal pattern differences.

This study shows azacytidine improves T cell function in AML by altering DNA methylation and reducing T cell exhaustion.

This study identifies astrocyte reactivity in the central amygdala due to ethanol dependence through multi-omics analysis in mice, revealing adaptive and maladaptive changes in neuroimmune and cytoskeletal pathways.

This study identifies epigenetic and transcriptomic changes in the hippocampus and blood of an Alzheimer's mouse model before amyloidosis onset, suggesting blood methylation as a potential biomarker.

This study shows that bisphenol A inhibits cancer-protective ESR1 signaling in human liver cells at environmentally relevant doses, suggesting it promotes liver cancer.

This study identifies astrocyte-specific gene and pathway changes in the nucleus accumbens during alcohol dependence using RNA-Seq and TRAP, revealing distinct immune activation patterns compared to ethanol drinking.

The paper develops a high-throughput assay to test retrotransposon jumping activity and identifies variants that influence transposition.

The paper presents haplotype-resolved genomes of six ape species with high accuracy and provides comparative analyses to study evolutionary diversity and gene family evolution.

The paper shows that ethanol inhibits astrocyte translation of Chpf2 and Chsy1, reducing CS-GAGs and increasing dendritic arborization in hippocampal neurons.

The paper identifies centromeric transposable elements and epigenetic features in the eastern hoolock gibbon that contribute to karyotypic variation and chromosomal instability.

This study shows that deleting a conserved TAD boundary near Dmrtb1 and Lrp8 in mice impairs spermatogenesis but not fertility.

The paper produces gapless assemblies of ape sex chromosomes for five great apes and a lesser ape, revealing divergence in Y chromosomes and evolutionary dynamics.

The paper identifies structurally divergent regions in primate genomes and quantifies the impact of structural variants across multiple species.

GoPeaks is a peak calling method for CUT&Tag data that improves sensitivity in detecting H3K27Ac peaks compared to standard algorithms.

This study examines ERVK11q23.3 expression in placental tissues, finding it upregulated in preterm placenta, expressed by trophoblasts, and involved in immune responses linked to preterm birth.

The paper compares transcriptomes of human and rhesus placenta, identifies differentially expressed genes, and develops novel rhesus trophoblast cell lines for studying placentation.

The paper investigates molecular mechanisms of aneuploidy during early mammalian embryogenesis, revealing the role of mitotic checkpoint proteins and chromosomal mis-segregation in developmental arrest.

This study examines how chromosomal rearrangements in the gibbon genome affect TAD boundaries and epigenetic features, finding overlap between rearrangement breakpoints and TAD boundaries.

The paper uses single-cell DNA sequencing in non-human primates to show that chromosomal errors in embryos are encapsulated into micronuclei, fragmented, or excluded to prevent aneuploidy.