Yemil Atisha‐Fregoso

This study compares B-cell subsets in active SLE, remission, and healthy controls to identify immunological differences and potential therapeutic targets.

The paper identifies a subgroup of SLE patients with high plasmablast frequency and IFN signature, enriched in those with Sm/RNP antibodies, linking IFN to B cell hyperactivity and autoantibody production.

The paper shows LAIR1 expression decreases during B cell differentiation and is regulated by the IL-21/STAT3 pathway, with implications for B cell autoreactivity and systemic lupus erythematosus.

This study analyzes B cell receptor sequences in SLE patients to understand autoreactive B cell selection and differentiation, finding that ABCs are enriched in autoreactivity and may arise from naive B cells through an extrafollicular pathway.

The paper shows that ultrasound neuromodulation of the spleen reduces experimental pulmonary hypertension by improving hemodynamics and reducing inflammation.