Ines S. C. Baptista

The paper investigates how premature terminations and internal promoters affect operon responses during genome-wide stresses in bacteria.

The paper studies transcription attenuation in synthetic tandem promoters in E. coli, finding that promoter positioning and factors like rifampicin influence attenuation through RNAP collisions.

The paper develops a library of fluorescent reporters for 16 global regulators in E. coli to track their activity under various growth and stress conditions.

The paper models gene promoters with dual σ factor preference in E. coli, showing sequence-dependent sensitivity to σ70 and σ38 and proposing a generalizable framework for synthetic biology applications.

The paper examines how changes in RNA polymerase concentration affect gene expression in E. coli, finding that mid-term responses correlate with transcription factor network topology.

The paper develops an analytical model of gene expression dynamics for tandem promoters in E. coli, showing that transcription interference depends on RNAP occupancy time and distance between transcription start sites.

The paper identifies cold shock repressed genes in E. coli and shows their responsiveness is linked to positive supercoiling buildup and Gyrase inhibition.