Rahul Jagadeesan

The paper introduces a coherence matrix to analyze directional regulatory coordination in gene regulatory networks, showing how hierarchical structures mitigate scaling penalties in sparse networks.

The paper shows that thermal shifts override antibiotic effects in E. coli by altering transcriptomes and physiological responses across multiple levels.

The paper shows that transcription attenuation modulates both burst size and frequency from a σ70 promoter, challenging previous views on frequency modulation and revealing cross-feeding as a strategy for controlling gene expression variation.

This study identifies genome-wide transcriptional mechanisms in E. coli under non-lethal rifampicin stress, showing gene regulatory network structure influences response dynamics and phenotypic adaptations.

The paper investigates how premature terminations and internal promoters affect operon responses during genome-wide stresses in bacteria.

The paper studies transcription attenuation in synthetic tandem promoters in E. coli, finding that promoter positioning and factors like rifampicin influence attenuation through RNAP collisions.

The paper develops a library of fluorescent reporters for 16 global regulators in E. coli to track their activity under various growth and stress conditions.

The paper identifies cold shock repressed genes in E. coli and shows their responsiveness is linked to positive supercoiling buildup and Gyrase inhibition.