ImmunologybioRxivPreprint
Deconstructing CTL-mediated autoimmunity through weak TCR-cross-reactivity towards highly abundant self-antigen
Angelika Plach, Vanessa Mühlgrabner, Aleksandra Rodak…·Johannes B. Huppa
The paper uses live-cell imaging to study TCR:pMHC interactions in anti-viral and autoimmunity settings, revealing differences in synaptic engagement, CD8 co-engagement, and signaling efficiency that define central tolerance boundaries.
DOI 10.1101/2024.08.17.608371