Deconstructing CTL-mediated autoimmunity through weak TCR-cross-reactivity towards highly abundant self-antigen
Angelika Plach, Vanessa Mühlgrabner, Aleksandra Rodak, René Platzer, Iago Doel Perez, Paul Fellinger, Timo Peters, Yvonne Winhofer, Christoph Madritsch, Lukas Schrangl, Hannes S. J. Stockinger, Loı̈c Dupré, Dirk Hans Busch, Kilian Schober, Janett Göhring, Johannes B. Huppa
The paper uses live-cell imaging to study TCR:pMHC interactions in anti-viral and autoimmunity settings, revealing differences in synaptic engagement, CD8 co-engagement, and signaling efficiency that define central tolerance boundaries.
bioRxiv · Aug 17, 2024 · PreprintImmunology