CD4+ T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions
Lukas Schrangl, Florian Kellner, René Platzer, Vanessa Mühlgrabner, Paul Hubinger, Josephine Wieland, Reinhard Obst, José Luis Toca-Herrera, Johannes B. Huppa, Gerhard J. Schütz, Janett Göhring
The paper quantifies mechanical forces on TCR:pMHC interactions in CD4+ T-cells, finding low forces that do not affect bond lifetimes, suggesting the immunological synapse stabilizes antigen recognition.
Nature Communications · Aug 14, 2025Peer-reviewedImmunology