Author

Abdallah A. Mohamed

Massachusetts Institute of TechnologyORCID 0000-0001-7057-5721Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Seychelle M. VosiD· 2 shared David P. BarteliD· 1 shared Peter Y. WangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBiochemistry

Seychelle M. VosORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 7, 2026

Structural basis for P-TEFb association with BRD4

Abdallah A. Mohamed, Seychelle M. Vos

This study identifies the structural basis of BRD4 interaction with P-TEFb and shows how BRD4 and AFF4 regulate P-TEFb activity through distinct mechanisms.

DOI 10.64898/2026.09.03.749171

structural biologyexperimental assay

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Molecular BiologyCell ReportsPeer-reviewedDec 31, 2024

The structural basis for RNA slicing by human Argonaute2

Abdallah A. Mohamed, Peter Y. Wang, David P. Bartel, Seychelle M. Vos

This paper presents the cryo-EM structure of a human AGO-guide complex bound to a fully paired target, revealing structural rearrangements that enable slicing-competent conformation and explain RNA slicing mechanism.

32 citationstop 4%

humanexperimental assay

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