Jeremy Freeman

cellxgene couples a Python server to a browser-based JavaScript client, letting researchers cross-filter, re-embed, annotate, and test differential expression in datasets of millions of cells.

The paper investigates how local recurrent circuits in the somatosensory cortex amplify sensory signals through subnetworks with elevated connectivity, showing that targeted ablation of specific neurons disrupts stimulus encoding.

The paper benchmarks spike rate inference algorithms for two-photon calcium imaging data and finds that top-performing algorithms show high correlation despite diverse approaches.