ImmunologybioRxivPreprint
Loss of B cell tolerance at the T2/T3a B cell transition is a convergent pathogenic mechanism in common variable immunodeficiency
Kirsty Hillier, Grace J. Yuen, Anson Hui…·Shiv S Pillai
The paper identifies loss of transitional B cell tolerance and extrafollicular expansion of autoreactive B cells as a common mechanism driving autoimmunity in monogenic CVID.