Michelle L. Ramseier

Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data

This paper introduces NCLUSION, a nonparametric clustering method for scRNA-seq that identifies marker genes and clusters simultaneously, showing improved performance and reduced runtime.

Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival

The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.

A knockoff calibration method to avoid over-clustering in single-cell RNA-sequencing

This paper introduces a method to prevent over-clustering in scRNA-seq by controlling double-dipping, improving differential expression analysis accuracy.

Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease

This study identifies mutation and transcriptional state compatibility in Ph+ ALL MRD, showing that targeting these interactions can overcome BCR::ABL1 independence and improve MRD monitoring.

Congenital T cell activation impairs transitional to follicular B cell maturation in humans

Congenital T cell activation in CTLA4-deficient patients impairs transitional to follicular B cell maturation and can be rescued by CTLA4 replacement therapy in vivo.