Richard A. O’Connor

Direct and indirect LPS injury in human donor lungs produce distinct 4 h proteomic programs; signature reversal favours SYK, CDK, HDAC, JAK/STAT and PI3K/AKT/mTOR pathway modulation.

This paper demonstrates the use of endomicroscopic fluorescence lifetime imaging with targeted probes to detect bacteria and neutrophils in the distal human lung, enabling real-time molecular imaging and sampling.