Annya M. Bruce

Beyond Navigation - Tissue-contacting Fluorescent Lifetime Imaging reveals a pathology-linked lung cancer phenotype at the point of biopsy

The paper validates a tumour-associated phenotype identified by FLIM in lung cancer biopsies, showing it is reproducible across imaging systems and distinguishable from normal tissue.

Therapeutic signature mapping of paired direct and indirect LPS injury in an ex vivo human lung perfusion platform reveals injury-specific druggable programs

Direct and indirect LPS injury in human donor lungs produce distinct 4 h proteomic programs; signature reversal favours SYK, CDK, HDAC, JAK/STAT and PI3K/AKT/mTOR pathway modulation.

Endomicroscopic fluorescence lifetime imaging enables molecular detection and targeted sampling in the distal human lung

This paper demonstrates the use of endomicroscopic fluorescence lifetime imaging with targeted probes to detect bacteria and neutrophils in the distal human lung, enabling real-time molecular imaging and sampling.