MicrobiologybioRxivPreprint
Two birds with one stone: a novel potential antibiotic blocking IsdB-mediated heme extraction by Staphylococcus aureus with serendipitous hemoglobin left-shifting activity
Sarah Hijazi, Francesco Marchesani, Marialaura Marchetti…·Stefano Bettati
This paper identifies C35 as a dual-acting compound that inhibits Staphylococcus aureus growth by blocking heme acquisition and modulates hemoglobin oxygen affinity.
DOI 10.1101/2025.05.29.656759