Mayank Murali

The paper maps context-dependent genetic regulation of cardiometabolic loci in human adipocytes using a multi-donor cell village system and single-nucleus multiome sequencing under various metabolic stress conditions.

This study identifies 282 genetic loci associated with insulin resistance through multi-trait GWAS, highlighting adipose-specific and systemic regulators and potential therapeutic targets.

This study identifies 12 enhancers in the 9p21.3 CAD risk locus that regulate MTAP, modulating vascular cell-state transitions and CAD risk through stress-responsive mechanisms.

Biosurfer identifies sources of protein isoform diversity by analyzing long-read RNA-seq data, revealing common mechanisms like alternative transcription start sites and 'ragged codons'.

This paper connects disease-associated splicing QTLs to protein isoform effects using long-read RNA-seq and GWAS data in osteoblasts.

The paper uses long-read proteogenomics to characterize protein isoform diversity in HUVECs, identifying novel transcripts and isoforms with potential functional implications.