Abdullah Abood

This paper connects disease-associated splicing QTLs to protein isoform effects using long-read RNA-seq and GWAS data in osteoblasts.

The paper evaluates a scalable approach using scRNA-seq to generate cell-type specific transcriptomic profiles of mesenchymal lineage cells from mouse bone marrow-derived stromal cells.

The paper shows genetic differences affect bone loss in mice under unloading, with specific strains showing greater bone volume and strength loss.

The paper identifies 58 long non-coding RNAs potentially responsible for BMD GWAS associations by combining allelic imbalance, TWAS, and eQTL colocalization analyses.