The non-steroidal mineralocorticoid receptor (MR) antagonist (FINERENONE) reverses Western diet-induced kidney disease by enhancing mitochondrial metabolism and decreasing lipid accumulation and inflammation
Komuraiah Myakala, Xiaoxin X. Wang, Nataliia V. Shults, Eleni P. Hughes, Patrícia de Carvalho Ribeiro, Rozhin Penjweini, Katie A. Link, Keely Barton, Ewa Krawczyk, Cheryl Clarkson Paredes, Anastas S. Popratiloff, Jay R. Knutson, L. Ashley Cowart, Moshe Levi
This study shows that Finerenone reduces kidney disease in mice by improving mitochondrial function, lowering lipid accumulation, and reducing inflammation.
American Journal of Physiology-Renal Physiology · Sep 29, 2025Peer-reviewedPharmacology & Toxicology