L. Ashley Cowart

Impact of the sphingolipid metabolizing enzyme β-galactosylceramidase on mitochondrial sphingolipid profile and energetic metabolism in human melanoma cells

This study shows that knocking out β-galactosylceramidase in human melanoma cells reduces mitochondrial sphingolipids, leading to impaired energy metabolism and bioenergetic insufficiency.

Impaired proteostasis is an early feature of the diabetic heart in humans and mice

This study shows that impaired proteostasis is an early feature of diabetic cardiomyopathy in humans and mice, with intermittent fasting offering protective effects.

Depot-specific roles for sphingosine kinase 1 in conversion of white adipose to thermogenic adipose

This study investigates the role of SphK1 in adipose thermogenesis and mitochondrial function, finding depot-specific effects on beiging and metabolic outcomes.

The non-steroidal mineralocorticoid receptor (MR) antagonist (FINERENONE) reverses Western diet-induced kidney disease by enhancing mitochondrial metabolism and decreasing lipid accumulation and inflammation

This study shows that Finerenone reduces kidney disease in mice by improving mitochondrial function, lowering lipid accumulation, and reducing inflammation.

Dyslipidemic SPTLC3 Integrates Bile Acid-FXR Signaling with Sphingolipid Remodeling in MASLD

This study identifies SPTLC3's role in integrating bile acid-FXR signaling with sphingolipid remodeling in MASLD, showing its dysregulation in human liver and association with disease.

Aramchol attenuates fibrosis in mouse models of biliary fibrosis and blocks the TGFβ-induced fibroinflammatory mediators in cholangiocytes

This study shows Aramchol reduces fibrosis in mouse models of biliary disease by inhibiting TGFβ-induced inflammation and fibrotic markers in cholangiocytes.

Sphingosine kinase 1 is induced by glucocorticoids in adipose derived stem cells and enhances glucocorticoid mediated signaling in adipose expansion.

This study shows glucocorticoids induce SphK1 in adipose-derived stem cells, which enhances glucocorticoid signaling and adipose expansion, though SphK1 is not essential for adipogenesis.

Adipocyte sphingosine kinase 1 regulates histone modifiers to disrupt circadian function

This study shows that SphK1, a circadian-regulated gene in adipocytes, affects histone modifiers and disrupts circadian function through altered histone acetylation and HDAC localization.