Author

Jie Ruan

BGI Group (China)ORCID 0000-0001-7144-8716Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:variant calling· 2 Research Focus:variant effect prediction· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrei Alexeev· 1 shared Bahram Ghaffarzadeh Kermani· 1 shared Chao DongiD· 1 shared Chao NieiD· 1 shared Han Ren· 1 shared Hanjie Shen· 1 shared Hanmin Wei· 1 shared Huanming Yang· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

Andrei Alexeev

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintNov 18, 2020

LFMD: detecting low-frequency mutations in high-depth genome sequencing data without molecular tags

Rui Ye, Xuehan Zhuang, Jie Ruan…·Pak Chung Sham

LFMD improves low-frequency mutation detection in high-depth sequencing by combining duplex sequencing and bottleneck sequencing to enhance sensitivity and specificity.

DOI 10.1101/617381

whole-genome sequencingstatistical model

𝕏 PostBluesky

GenomicsDNA ResearchPeer-reviewedMay 8, 2019

Development of Coupling Controlled Polymerizations by Adapter-ligation in Mate-pair Sequencing for Detection of Various Genomic Variants in One Single Assay

Zirui Dong, Xia Zhao, Qiaoling Li…·Yuan Jiang

This paper introduces a new mate-pair sequencing method called CP-AL that improves DNA-circularization efficiency and reduces contamination, enabling accurate detection of genomic variants.

26 citations

humanwhole-genome sequencing

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