Xia Zhao

The paper introduces a de novo scaffolding tool for synthetic long reads that improves assembly quality significantly, especially for assemblies from next-generation sequencing reads.

AsmMix produces high-quality diploid genome assemblies by integrating co-barcoded and single-molecule sequencing data to reduce errors and improve contiguity.

This study evaluates CNV detection performance of DNBSEQ and Illumina platforms using WGS data from NA12878, showing DNBSEQ detects more CNVs with similar sensitivity and precision.

This paper introduces a new mate-pair sequencing method called CP-AL that improves DNA-circularization efficiency and reduces contamination, enabling accurate detection of genomic variants.

The paper evaluates index mis-assignment rates on DNB-based sequencing platforms and finds they are exceptionally low, suggesting reliable multiplex sequencing.

The paper introduces a novel ligation method called 3BL that allows non-complementary DNA to be ligated to 3' ends of DNA or RNA, improving NGS library construction by reducing adapter dimer issues and increasing yield.