Author

Malcolm A. Leissring

University of California, IrvineORCID 0000-0001-7185-4255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1

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Abigail Wiseman· 1 shared Derek S. Maranan· 1 shared Dylan D. Butler· 1 shared Frank M. LaFerlaiD· 1 shared Heather M. Terron· 1 shared Luke A. BurgardiD· 1 shared Sagar J. Parikh· 1 shared Shelley Lane· 1 shared

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2025-2025 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperMolecular Biology

Abigail Wiseman

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1 paper

Recent·Most cited

Molecular BiologyCellsPeer-reviewedApr 3, 2025

Targeted control of gene expression using CRISPR-associated endoribonucleases

Sagar J. Parikh, Heather M. Terron, Luke A. Burgard…·Malcolm A. Leissring

This paper introduces DREDGE, a method using CRISPR-associated endoribonucleases to regulate gene expression by targeting direct repeats in the 3' untranslated region, achieving up to 90% downregulation in a reversible manner.

1 citation

CRISPR screenexperimental assay

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