Frank M. LaFerla

This paper introduces DREDGE, a method using CRISPR-associated endoribonucleases to regulate gene expression by targeting direct repeats in the 3' untranslated region, achieving up to 90% downregulation in a reversible manner.

The paper investigates how the APOE Christchurch variant affects microglial responses to amyloid and tau pathology in mouse models, finding it enhances plaque-related responses but suppresses tau-related inflammation.

This paper characterizes the 3xTg-AD mouse model of Alzheimer's Disease across its lifespan and compares it with the 5xFAD model to assess pathology and model drift.

The paper performs a comprehensive phenotypic analysis of the 5xFAD mouse model across its lifespan, identifying novel age-related pathological features.

The paper uses single-cell and nucleus RNA-seq to analyze glial subpopulations in AD mouse models, finding differences in astrocyte activation and microglia subtypes between 3xTg-AD and 5xFAD models.

The paper investigates spatial reorientation deficits in 3xTg-AD mice, finding impaired performance in female mice but not males, suggesting a sex-dependent effect of AD on spatial orientation.