Sergei V. Strelkov

This study examines how desmin mutations affect filament assembly and aggregation, finding that specific mutations disrupt filament maturation and lead to distinct aggregation pathways.

The paper describes the structural analysis of lamin A using chimeric fusions to form coiled-coil dimers, resulting in crystal structures solved at 1.83 and 2.9 Å resolution.

The paper develops a data-driven method to parameterize coiled coil structures using principal component analysis, validated on parallel CC dimers.

The paper introduces a Z-score metric to evaluate the quality of SAXS-based macromolecular models by assessing their ability to differentiate between possible structures.

CCFold predicts coiled-coil structures accurately and rapidly, enabling modeling of intermediate filament dimers.