Gang Chen

Helminth infection induces RELMa-dependent adipose tissue transcriptional reprogramming and protection against diet-induced obesity

This study shows that helminth infection via RELM reduces diet-induced obesity by altering adipose tissue transcription and function in mice.

Pathology-Targeted EP4 Agonism Reverses Fibrosis in a Rat Model of DMD

This study shows that Irodanoprost, a bone-targeted EP4 agonist, reduces fibrosis and restores muscle regeneration in a rat model of Duchenne muscular dystrophy.

Multi-ancestry Genome-wide Association Study of Creatine Kinase Highlights the Genetic Basis of Muscle Damage

This study identifies 107 genetic loci associated with serum creatine kinase levels across diverse populations, highlighting genes involved in muscle structure and function.

Leveraging the local genetic structure for trans-ancestry association mapping

This paper introduces LOG-TRAM, a method to improve trans-ancestry association mapping by leveraging local genetic structure, enhancing power and reducing bias in under-represented populations.

The High-resolution Timeline of Expression of Ribosomal Protein Genes in Yeast

The paper estimates the high-resolution timeline of ribosomal protein gene expression in yeast, showing a 25-minute sequence with genes for mature ribosome proteins expressed later than others involved in biogenesis.

Is the Statistic Value All We Should Care about in Neuroimaging?

The paper argues that neuroimaging studies should report effect estimates alongside statistical values to improve reliability and interpretability.

Sharing brain mapping statistical results with the neuroimaging data model

This paper introduces NIDM-Results, a standardized format for sharing neuroimaging statistical results, enabling reproducibility and meta-analysis.