David Holmberg

Single-cell morphological profiling reveals insights into programmed cell death

The paper compares single-cell and aggregated morphological profiling to identify programmed cell death mechanisms, finding aggregated data performs better in supervised models.

The time dimension matters: Improving mode of action classification with live-cell imaging

This paper introduces LCTP, a workflow for analyzing live-cell time series data to improve mode of action classification by capturing temporal phenotypes across compounds and cell lines.

High-content morphological profiling by Cell Painting in 3D spheroids.

This paper introduces a method to apply Cell Painting to 3D spheroids for morphological profiling, detecting phenotypic changes in colorectal cancer cells under compound treatments.