This paper introduces a method to apply Cell Painting to 3D spheroids for morphological profiling, detecting phenotypic changes in colorectal cancer cells under compound treatments.

bioRxiv · Feb 5, 2025 · PreprintPharmacology & Toxicology

Foxj1 controls olfactory ciliogenesis and differentiation program of the olfactory sensory neurons

Dheeraj Rayamajhi, Mert Ege, Kirill Ukhanov, Christa Ringers, Yiliu Zhang, Inyoung Jeong, Percival P. D’Gama, Summer Shijia Li, Mehmet İlyas Coşacak, Çağhan Kızıl, Hae‐Chul Park, Emre Yaksi, Jeffrey R. Martens, Steven L. Brody, Nathalie Jurisch‐Yaksi, Sudipto Roy

This study identifies Foxj1's role in regulating olfactory cilia formation and OSN differentiation in zebrafish and mice.

PLoS Biology · Jan 25, 2024Peer-reviewedNeuroscience

Diversity and Function of Motile Ciliated Cell Types within Ependymal Lineages of the Zebrafish Brain

Percival P. D’Gama, Tao Qiu, Mehmet İlyas Coşacak, Dheeraj Rayamajhi, Ahsen Konac, Jan N. Hansen, Christa Ringers, Francisca Acuña, Subhra Prakash Hui, Emilie Willoch Olstad, Yan Ling Chong, Charlton Kang An Lim, Astha Gupta, Chee Peng Ng, Benedikt S. Nilges, , Nathalie Jurisch‐Yaksi

The paper characterizes motile ciliated cells in zebrafish brain ventricles, showing their developmental origins, functional roles in CSF flow, and impact on ventricular morphology.

Cell Reports · Oct 1, 2021Peer-reviewedNeuroscience

Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis

Stephanie Fore, Francisca Acuña, Aytac Kadir Mutlu, Ewelina Magdalena Bartoszek, Bram Serneels, Nicholas Faturos, Khac Thanh Phong Chau, Mehmet İlyas Coşacak, Carmen Diaz Verdugo, Fabrizio Palumbo, Christa Ringers, Nathalie Jurisch‐Yaksi, Çağhan Kızıl, Emre Yaksi

This study shows that habenular neurons develop sequentially, with their functional properties determined by their birthdate during development.

Science Advances · Sep 4, 2020Peer-reviewedNeuroscience